大家知道路易莎是怎麼在 15 年內開出 500 多間店的嗎?
2/23/2024侯宗🌧️
10/26/2023AbstractFor the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in various forms of pathophysiology generally associated with aging. Our view of oxidative stress has been largely “superoxide-centric”, as we focused on the pathological sources of this oxygen-derived free radical and the types of molecular havoc it can wreak, as well as on the protection provided by the antioxidant enzymes, especially the superoxide dismutases, catalases, and glutathione peroxidases. In the last decade our view of oxidative stress has broadened considerably, and it is now often seen as an imbalance that has its origins in our genes, and the ways in which gene expression is regulated. At the center of this new focus is the transcription factor called nuclear factor (erythroid-derived 2)-like 2, or Nrf2. Nrf2 is referred to as the “master regulator” of the antioxidant response, modulating the expression of hundreds of genes, including not only the familiar antioxidant enzymes, but large numbers of genes that control seemingly disparate processes such as immune and inflammatory responses, tissue remodeling and fibrosis, carcinogenesis and metastasis, and even cognitive dysfunction and addictive behavior. Thus, the dysregulation of Nrf2-regulated genes provides a logical explanation for the connections, both direct and indirect, between observable oxidative stress and perhaps 200 human diseases involving these various physiological processes, each reflecting a network involving many gene products. The evolutionary self-association of these many genes under the common control of Nrf2 suggests that the immune and inflammatory systems may present the largest demand for increased antioxidant protection, apart from constitutive oxidative stress resulting from mitochondrial oxygen consumption for metabolic purposes. Gene expression microarray data on human primary vascular endothelial cells and on the SK-N-MC human neuroblastoma-derived cell line have been obtained in response to the dietary supplement Protandim, a potent composition of highly synergistic phytochemical Nrf2 activators. Pathway analysis of results shows significant modulation by Protandim of pathways involving not only antioxidant enzymes, but of those related to colon cancer, cardiovascular disease, and Alzheimer disease.
10/16/2023文件 文件別全形、半形字跟標點符號混雜。 投影片要上頁碼,Feedback Q&A 才知道要討論哪裡。 文件條列式編碼不要要自己打,要使用預設編碼功能。 Ctrl+S 隨時存擋、Ctrl+Z 復原、Ctrl+Shift+V 去格式貼上等快捷鍵很好用。 Word 換頁不要一直按 enter,用分頁符號 / Ctrl+Enter。 進階:學會 VLOOKUP 怎用。 複製貼上要懂得用文字編輯器洗掉格式;至少要用 Ctrl+Shift+V。 文件正確的使用標點符號,還有善用 tab 鍵。 文件要使用追蹤修訂、修訂建議功能。 使用方法
9/11/2023or
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