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--- tags: Lab --- # IJV | 模擬架構規劃 July, 2021 [toc] ## 硬體設定 ### i. 光源 - 規格 - 實體圖 ![](https://i.imgur.com/3r9wjYK.png =30%x) - 尺吋 1. 正方形邊長: 30 mm 2. 中央出光孔半徑: 5 mm - LED panel 與血管的相對方向 ![](https://i.imgur.com/aUiheyx.png =25%x) - holder 與皮膚之間會有水嗎? ### ii. 偵測器 - 規格 - 尺吋 1. Holder - 長邊: 14.06 mm - 短邊: 12.13 mm 2. Prism - 邊長 5 mm 之等腰直角三角形 - 實體圖 ![](https://i.imgur.com/tbegJQD.jpg =30%x) - Holder 折射率 - 材質:Poly Lactic Acid, PLA - 680-810nm 範圍內的折射率 ![](https://i.imgur.com/Xoohesg.png =80%x) - 資料來源: [Optical Properties of Polylactides](https://link.springer.com/article/10.1007/s10924-006-0001-z) - 稜鏡折射率 - 使用的稜鏡型號為 → [PS909, THORLAB](https://www.thorlabs.com/thorproduct.cfm?partnumber=PS909),與胤甫、哲皓使用的型號相同。 - 材料 → N-BK7。 - 折射率計算公式(Sellmeier Equation)與[來源](https://www.thorlabs.com/newgrouppage9.cfm?objectgroup_id=6973&tabname=n-bk7)。(另一個可供參考之[網站](https://refractiveindex.info/?shelf=glass&book=BK7&page=SCHOTT), given by THORLAB Tech Support) ![](https://i.imgur.com/7fz6j2E.png) *unit of λ in the above formula → μm - 位於 IJV 使用波長範圍內之折射率 (Maximum ≈ 1.5136, Minimum ≈ 1.5106) ![](https://i.imgur.com/MgVZXHs.png =80%x) - 光纖 full acceptance angle - 數值孔徑, NA 根據老師提供的資料,我們所使用的光纖NA為==0.22==。 ![](https://i.imgur.com/0cHEja6.png) - Full acceptance angle 計算 光纖的 full acceptance angle 計算公式為 2 x sin^-1^(NA/n_prism),代入不同波長下的 n_prism,可見下圖的涵蓋範圍。 ![](https://i.imgur.com/Pkht01B.png =80%x) - 光纖bundle等效直徑計算 ![](https://i.imgur.com/K2oewyO.jpg) - 模擬方式: 1. 一般方式: 空氣的 n 設為 1.0,detector 緊貼皮膚表面,光子離開皮膚時**會偏折**。 2. 子佳碩論方式: 空氣的 n 設為 1.4(相當於 PDMS 的 n),detector 緊貼皮膚表面,光子離開皮膚時**不會偏折**。(實驗的 source 端與 detector 端皆有塗導膠?) - 優點 → ==source與皮膚==以及==detector與皮膚==之間皆為index-matched,收光效率好。 - 缺點 → 光子於 source - detector 之間較容易穿出皮膚 3. IJV 可行方式(不修改 MCX source code,以 detector 位於第一層組織之表面) - 仿照子佳碩論,只是 detector 的半徑採用經過**稜鏡**後的等效半徑。模擬完後再後續分析真正進入 detector 的光子。(此方式實驗也需貼 **PDMS** 或相同光學性質之材料) - 皮膚上方加一層類似 **PLA** 性質的組織(n = 1.4, mus 設極小),此組織的大小相當於 PLA 裝置的大小(PLA 下方需塗導膠嗎?) 4. ==**最終 IJV 採用之模擬方式(暫訂)**== - MCX ![](https://i.imgur.com/7WYy5VE.png) - 對照之真實情況(並未 follow 真正擺設之方向) ![](https://i.imgur.com/FHAhQav.png) ### iii. 光源 ↔ 偵測器方向 - 位於 ijv 正上方 - 與 ijv 平行 ## 組織模型設定 ### i. 組織物件建立順序(圖層概念,尚未知是否可行) - 0^th^ layer **(Background layer)**: Air, ++Grid++ - 1^st^ layer: Source PLA, ++SubGrid++ - 2^nd^ layer: Detector PLA, ++SubGrid++ - 3^rd^ layer: Source Air **(A space where photons launch)**, ++Cylinder++ - 4^th^ layer: Detector Prism **(A space where photons can be detected)**, ++SubGrid++ - 5^th^ layer: Skin, ++Z Layer++ - 6^th^ layer: Fat, ++Z Layer++ - 7^th^ layer: Muscle, ++Z Layer++ - 8^th^ layer: IJV, ++Cylinder++ - 9^th^ layer: CCA, ++Cylinder++ ### ii. 幾何參數 1. Background layer 2. 1st layer 3. 2nd layer ### iii. 光學參數 1. Background layer 2. 1st layer 3. 2nd layer ## MCX 細節參數設定 1. OriginType 2. Boundary reflect 3. etc... ## 觀念 1. 要視情況,雖然時常是模擬配合實驗,但有時也要讓實驗配合模擬。**`例如`**:當 PLA 與皮膚之間很難確保無空氣時,這時可以塗上一層 gel (index-matched with skin),而不是硬是在模擬的 PLA 與皮膚之間加一層空氣。gel 的作用也可以降低雜訊。 ## 相關問題 1. 稜鏡造成的衰減是由校正去補足嗎? 2. 稜鏡斜面要保有空氣? 3. 如果有碰到稜鏡斜面又跑回組織的光子? 4. 碰到皮膚表面又反射回 filter 又反射回皮膚的光子? 5. 之前 pattern 的模擬,光是從空氣進入的嗎? 6. 實際的紅光 pattern 的半徑應會比模擬來得小,此為最後結果的可能誤差來源。 ## 備註 1. 模型假設 - Source 端: 模擬的 pattern 與實驗量取的 pattern 吻合,因此不需擔心++從皮膚反射回 filter 再反射回皮膚++的光子。**不過要注意的是,比較的對象是,皮膚的第一層吸收分佈 v.s. 光穿過白紙後被相機感測到的 R channel 分佈。** - Detector 端: 忽略++從稜鏡內反射回皮膚++與++在稜鏡內反射++的光子 ## 待辦 1. ~~試著再想想目前模型的設定方式有沒有問題,有沒有沒考慮到的、突發狀況的?~~ 2. ~~試著給 MCX Cloud 的 preview 驗證形狀有無符合想像~~ 3. ~~拍 source 照片~~ 4. 實作 - 整個組織模型需要多大?source 在中央還是 source 與 detector 的中心點在中央? - 幾何參數量測 - mua, mus, n, g 數值確認 - mcx 細節參數確認 - 全部的 output 可以以 jdata 形式輸出, source code compile, mcx code 整理 (類別形式,可以與 mcx_train 互通) 9. 確認此份文件是否清楚 10. 給 KB 確認 11. 重灌電腦、確認要一次模擬多少個 sds (Sensitivity ??) 12. 開始模擬

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