How you can help

The most important piece of health advice

I think the most important piece of health advice for most people alive today is one that might sound rather strange: to contribute to the advancement of ageing biology. Successfully turning ideas in the lab into treatments for ageing is likely to be the single most important thing our generation can do to ensure that we, our friends and families, and people around the world can enjoy longer, healthier lives.

If you’d like to help, I’ve got two suggestions: first, write to your political representatives (your MP in the UK, your Congresspeople and Senators in the US, and so on) explaining the importance of funding biogerontology research to both health and economic prosperity; and second, if you want to directly support research, I’ve made a list of charitable organisations who are performing research into ageing biology.

This isn’t a complete list, so if you have any suggestions, please get in touch by email to let me know what I’ve missed or, even better, help me improve this page on collaborative editor HackMD!

Tell your politicians about biogerontology

Wherever you are in the world, you can write to politicians that represent you to tell them about the huge potential of ageing biology—and that, to secure your vote, they would do well to invest in it.

If you’re in the US, The Alliance for Longevity Initiatives is a new nonprofit aiming to raise the political profile of aging research.

Here are some general tips for making an effective case to a politician:

• Find the email address of the people who represent you!
  • In the US, you can use this page to find links on this page to write to local government, Representatives, Senators or the President.
  • In the UK, you can use this page to find your MP and their contact details, or you can contact them through www.writetothem.com. Remember to include your full name and home address with postcode in your message so your MP knows you’re a constituent.
• Keep your letter short and to the point. Politicians are very busy, and can receive hundreds of pieces of correspondence per day.
• Have a specific request—it could be as simple as that they find out more about ageing biology, or that they sign a petition or motion, or raise the issue with a relevant person or department. Asking for something specific makes it easier for the person you’re writing to to take action.
• If you have experience or expertise on the topic you’re writing on, briefly mention it to lend weight to your case.
• Make your letter personal, rather than just copying and pasting a form letter—this will make your message more powerful. Include your own stories where possible. For example, how has ageing affected you personally? Are you caring for a friend or relative, or maybe you or someone you know is a patient with an age-related disease? Are you a scientist or a doctor with an interest in this field?
• If there are specific issues that directly affect others in your constituency, town or state, mention this. Ageing of course affects all of us, but if there are issues specific to your area, your representative is more likely to be willing and able to engage.
• Find out some basic facts about whoever you’re contacting before getting in touch: which party they are part of may make a difference to what you say, or if they have a particular position in government or sit on a committee, it might be worth explaining the significance of ageing biology to their role.

I’ve adapted these from this page I co-wrote as part of a campaign with Science is Vital in the UK. My experience of political campaigning is UK-specific, so if you have any thoughts which are relevant to other countries, please let me know.

Other political support

• If you live in the EU, you can endorse this proposal for EU-level commitments to enable healthy longevity research and technologies.

Further reading

If you’d like to read more about how to use research funding to combat ageing from a policy perspective, you might find this submission I made to the UK’s House of Lords inquiry into ageing biology useful. Further policy recommendations can be found in the final Chapter of Ageless.

Donate to biogerontology charities

Each of these titles is a link to a page where you can donate to a particular organisation. Organisations are listed in reverse alphabetical order, and I have no affiliation with any of them—though in a few cases I interviewed scientists working at them while writing Ageless.

It’s worth checking whether gifts are tax deductible, or eligible for the similar Gift Aid scheme in the UK, as this may increase the amount you’re able to donate.

There is another useful list at AgingBiotech.info/nonprofits which it might also be worth checking out!

Charities in the US

University of Washington Healthy Aging and Longevity Research Institute

The HALO institute at UW works on a variety of projects aimed at understanding and intervening in the ageing process, including the Dog Aging Project, listed separately below.

SENS Research Foundation

The SENS (Strategies for Engineered Negligible Senescence) Research Foundation is developing therapies to repair damage accumulated during the aging process.

Robert and Arlene Kogod Center on Aging

The Kogod Center, based at the Mayo Clinic, works on a number of aspects of the aging process, the most famous of which is their pioneering work work on senescent cells and senolytic drugs that remove them.

National Institute on Aging (NIA)

Though the NIA is a taxpayer-funded government body in the US, it can accept private donations. When making a donation, you should designate funds for aging biology specifically by designating either the Division of Aging Biology, or one of the the NIA’s intramural research labs as the recipient of your donation. (This is important because for historical reasons the NIA invests a large amount of its research funding into Alzheimer’s disease rather than the aging process itself.)

Methuselah Foundation

The Methuselah Foundation supports a number of prizes and early-stage companies to encourage development of regenerative medicines against the diseases of ageing.

MDI Biological Laboratory

The MDI is a Maine-based independent nonprofit biomedical research institution, aiming ‘to improve human health by discovering fundamental novel mechanisms of tissue repair, aging and regeneration’.

lifespan.io

The Life Extension Advocacy Foundation (LEAF) runs crowdfunding campaigns for specific scientific projects, or you can ‘become a Lifespan Hero’ and help them continue to develop their community, conferences and events to raise the profile of biogerontology.

LEVF

The Longevity Escape Velocity Foundation is a new organisation founded by Aubrey de Grey that ‘exists to proactively identify and address the most challenging obstacles on the path to effective treatments to prevent and reverse age-related disease’. Its first big project is a study of combinations of therapies in mice.

Impetus Grants

Rapid grants of up to $500k for longevity research, with initial funding from the cryptocurrency community. Their goal is ‘to have a broad impact on the field, by supporting projects that challenge assumptions, develop new tools and methodologies, discover new ways to reverse aging processes, and/or synthesize isolated manifestations of aging into a systemic perspective.’ To donate, email donations@impetusgrants.com.

Dog Aging Project

The Dog Aging Project is enrolling thousands of dogs to study how their biology changes with age in detail, with the hope of applying the same insight to humans too. Some dogs will also be trialling anti-ageing drug rapamycin—a safety study has already shown that there are no serious side-effects, and that it improved heart health.

The Buck Institute

The Buck Institute is a California-based research institute dedicated entirely to understanding and treating aging.

American Federation for Aging Research (AFAR)

AFAR engages in policy advocacy and directly funds research into aging biology. It is also the organisation spearheading the TAME trial of metformin as a potential anti-aging drug.

An Lab

Jonathan An’s lab at the University of Washington, Seattle, researches ‘the underlying molecular and cellular mechanisms involved in oral disease and health as we age’. They are running a trial testing if rapamycin can improve oral health in older adults.

The Alliance for Longevity Initiatives (A4LI)

As mentioned above, A4LI is nonprofit focused on raising the political profile of aging research: in their own words, ‘advancing legislation, policies and initiatives that aim to increase healthy human lifespan’. They accept donations as well as volunteering time.

Albert Einstein College of Medicine

The Institute for Aging Research at Einstein has a number of aging research programs, most famously large studies of centenarians’ genetics and the TAME trial of metformin as a potential anti-aging drug. When donating, choose ‘Other fund’ as the designation, and in the Comment/Designate a program box, specify the Institute for Aging Research.

Charities in the UK

Genomics of Ageing and Rejuvenation Lab, University of Birmingham

The Genomics of Ageing and Rejuvenation Lab uses computational methods, such as analysing genome sequencing data, to understand the ageing process. Among other projects, they sequenced the genome of the exceptionally long-lived bowhead whale.

British Society for Research on Ageing (BSRA)

The BSRA funds research, PhD studentships and outreach and public engagement activities in the UK.

Biogerontology Research Foundation

The Biogerontology Research Foundation funds research and advocacy around ageing biology.

Charities in Switzerland

Longevity Science Foundation

A new foundation aiming for a ‘healthy human lifespan of 120+ years…within our lifetimes’, currently soliciting proposals for grant funding.