# Results Per Dataset
[toc]

| Data | Averaged ROC |
| -------- | -------- |
| Hoen and Yahr | 0.946 |
| Modified Schwab and England Score | 0.876 |
| Total UPDRS | 0.887 |
| UPDRS Pt II | 0.870 |
| UPDRS Pt III | 0.952 |
| UPSIT | 0.746 |
| PPMI DaTSCAN | 0.853 |
| Total REM Time | 0.724 |
| CSFSAA | 0.864 |

| Data | Averaged ROC |
| -------- | -------- |
| Total Sleep Time | 0.651 |
| Sleep Efficiency | 0.647 |

| Data | ATE (UPDRS Part III) |
| -------- | -------- |
| UPSIT | -8.75 |
| PPMI Left Putamen | -11.63 |
| PPMI Right Putamen | -10.13 |
| PPMI Left Caudate | -8.04 |
| PPMI Right Caudate | -7.53 |
| Total REM Time | 10.21 |
| CSFSAA | 12.06 |

| Data | ATE (UPDRS Part III) |
| -------- | -------- |
| Total Sleep Time | -5.13 |
| Sleep Efficiency | -6.50 |

| Data | ATE (UPDRS Part III) |
| -------- | -------- |
| Transformer Left Putamen | -3.98 |
| Transformer Right Putamen | -4.09 |
| Transformer Left Caudate | -3.9 |
| Transformer Right Caudate | -4.82 |
## Curated Data Cut
This data is the primary dataset I've been starting with because it has everything already organized. It includes everything that the main PPMI participants get tested on. However, that differs depending on which group the patient is in (PD,Prodromal,Control)
* **Parkinsons Disease Group Data**
* **ID Section**:
* **Site**
* **Participant ID**
* **Cohort at enrollment**
* PD, Prodromal, Healthy Patient
* **Analytic Cohort based on consensus committee review (CCR)**
* This changes for a few patients that start in Prodromal and move to PD group
* **Subgroup based on CCR**
* This is a subgroup based on whether the patients have either genetic identifiers or symptoms that link to the onset of Parkinsons.
* Sporadic (No history of PD. This is the most common), LRRK2 (Common genetic mutation), GBA (common genetic mutation), hyposmia (loss of smell), SNCA (Genetic Mutation), RBD (REM sleep disorder), PRKN (Young onset parkinsons genetic mutation)
* The majority of patients in the PD group are Sporadic, while the all of the patients in the prodromal group have one of the predictors since there is no predictor for sporadic
* **Event ID**
* When measurment was taken (Baseline - Visit 20)
* **Year**
* **Visit Date**

* **Demographics Section:**
* **Age at Enrollment**
* **Age at Visit**
* **Indicator for Ashkenazi Jewish/Berber/Basque descent**
* Common ascestory for patients with the above genetic mutations
* **Education Level**
* **Years of Education**
* **Family History of PD**
* **Handedness, Gender, Race, Sex, Hispanic ethnicity, Sexual Orientation**
* **Genetics Sections**
* **APOE**
* APOE is a genetic varient that has been linked to Parkinsons disease and Alzhiemers. APOE comes in three forms, or alleles, called 2, 3 and 4. Each patient has two alleles. Allel 2 and 4 have been linked to PD

* **Biologics Section**
**Early Diagnosis (Timepoint = BL)**

* **Abeta**
* CSF readings of A-beta 1-42 (pg/ml)
**Early Diagnosis (Timepoint = BL)**

* **Asyn**
* CSF readings of $\alpha$ synuclein (pg/ml). Out of all these asyn has been shown to be to best for early prediction while the others don't show much correlation

* **P-tau**
* CSF readings of Ptau (pg/ml)

* **T-tau**
* CSF readings of Ttau (pg/ml)

* **Urate**
* Serum Uric Acid in blood (mg/dl)

* **Hemohi**
* Level of CSF hemoglobin (pg/ml)

* **Urine BMP Totals**
* Elevated Urine bis(monoacylglycerol)phosphate (BMP) levels have been shown in patients with the LRRK-2 genetic mutation. Could be useful as an early biomarker

* **CSF/Serum Neurofilament Light**
* Neurofifilament light (NfL) is a neuron-specific protein component involved in the assembly and maintenance of the axonal cytoskeleton, which is elevated in CSF and serum due to axonal damage and neurodegeneration. Used as a biomarker for the progression of motor symptoms.

* **Datscan Section**
* **SBR for Left/Right Caudate and Putamen**
* It also indicates what side is Ipsliateral and Contralateral. And gives the mean values for the regions

* **Clinical Section** The Surveys are described in the data hack
* **Age at ..**
* Gives the age of the patient at Diagnosis, Pd symptom onset, age at LP, Age at DaTSCAN, age at Lumbar puncture, and age at UPSIT
* **BMI**
**Early Diagnosis (Timepoint = BL)**

* **Cognitive State Evaluation**
**Early Diagnosis (Timepoint = BL)**

* **Dominant Side of PD**
* **Duration from PD diagnosis to enrollment**
* **Benton Judgment of Line Orientation**
* This test measures a person's ability to match the angle and orientation of lines in space. It is evaluated out of 30.
**Early Diagnosis (Timepoint = BL)**

* **Total clock drawing score**
* Evaluation of a patient to draw clocks
**Early Diagnosis (Timepoint = BL)**

* **Epworth Sleepiness Scale Score**
* This test evaluates a person's sleepiness throughout the day. A patient is given 8 scenarios were they must give a sleepiness rating of 0-3, 0 no impairment - 3 falling asleep. It is evaluated out of 24 points.
**Early Diagnosis (Timepoint = BL)**

* **Geriatric Depression Scale Score**
* Evaluates whether a person is depressed or not. Scored out of 15 with a score greater than 5 representing depression. For each question 1 is yes, 0 is no.
**Early Diagnosis (Timepoint = BL)**

* **The Hopkins Verbal Learning Test**
* A test that measures verbal learning and memory. Envolves memorization of a list of words to test the ability to recall immediately after memorization (immediate recall) and after a 20-minute delay (delayed recall). The test is scored out of 36.
**Early Diagnosis (Timepoint = BL)**

* **Hoen and Yahr**
* The scale has been used for the staging of the functional disability associated with Parkinson's disease. It helps in describing the progression of the disease through various stages, thus allowing us to measure the severity of the case. Between 0 (no imparment) - 5 (max imparment)
**Early Diagnosis (Timepoint = BL)**

* **Lexical Fluency Score**
* used to assess language and executive function in clinical practice.
**Early Diagnosis (Timepoint = BL)**

* **Letter number sequencing score**
* It is a test that measures an individual's short-term memory skills in being able to process and re-sequence information. The participant must sequence a random order of numbers and letters. The total score for this test is 21.
**Early Diagnosis (Timepoint = BL)**

* **Modified Boston naming test score**
* consisting of 60 black and white line drawings of objects, is a measure of confrontation naming that takes into account the finding that patients with dysnomia often have greater difficulties with the naming of low frequency objects.
**Early Diagnosis (Timepoint = BL)**

* **Mild cognitive evaluation**
**Early Diagnosis (Timepoint = BL)**

* **MOCA**
* The montreal cognitive assessment is used to assess cognitive impairment. It is comprised of a variety of recognition tasks. It is scored out of 30 points. Correct answers are 1 point.
**Early Diagnosis (Timepoint = BL)**

* **Modified Schwab and England score**
* The patient is asked to evaluate how well they are able to live on their own with scores ranging from 0-100% in intervals of 10% with 100% representing complete independence and 0% representing a vegetative state.
**Early Diagnosis (Timepoint = BL)**

* **MDS-UPDRS parts I-IV**
* Total UPDRS is assessed by the following conditions:

1. Mentation, behavior, and mood
**Early Diagnosis (Timepoint = BL)**

2. Activities of daily living

3. Motor examination

4. Hoehn and Yahr staging scale

* **Orthostasis**
* evaluation of blood pressure change
**Early Diagnosis (Timepoint = BL)**

* **Total Levodopa Equivalent Daily Dose**
* Variable representing all medication
* **Quip**
* QUIP has 4 primary questions (pertaining to commonly reported thoughts, urges/desires, and behaviors associated with ICDs), each applied to the 4 ICDs (compulsive gambling, buying, eating, and sexual behavior) and 3 related disorders (medication use, punding, and hobbyism) evaluated on a 0-4 scale. QUIP is evaluated out of 112 points with our data representing it as a percentage.
**Early Diagnosis (Timepoint = BL)**

* **REM**
* Rapid eye movement sleep behavior disorderis one of the most specific prodromal indicators for Parkinson's disease. It is scored out of 10. Patients are asked questions about their sleep and enacting dreams.
**Early Diagnosis (Timepoint = BL)**

* **SCOPA**
* This test evaluates autonomic symptoms in patients with Parkinson’s disease. The 23 items of the SCOPA-AUT are grouped into six domains: gastrointestinal functioning (seven items), urinary functioning (six items), cardiovascular functioning (three items),thermoregulatory functioning (four items), pupillomotor functioning (one item), sexual function (two items for men and two for women). The maximum score is 69, with the score for each item ranging from 0 (never experiencing the symptom) to 3 (often experiencing the symptom).
**Early Diagnosis (Timepoint = BL)**

* **STAI**
* This test is used to measure anxiety in patients. 20 questions for both trait and state anxiety. Scores are given in a range from 1(almost never) - 4(almost always) with a max score of 160.
**Early Diagnosis (Timepoint = BL)**

* **UPSIT**
* Smell dysfunction occurs in 90% of cases with PD and has been shown to help distinguish PD from other parkinsonisms. The UPSIT is a measurement of the individual's ability to detect odors at a suprathreshold level. There are 40 questions in a scratch and sniff booklet. The patient assigns each smell from a list of 4 possible answers.
**Early Diagnosis (Timepoint = BL)**


* **Trails Making Test**
* It has two parts, in which the subject is instructed to connect a set of 25 dots as quickly as possible while maintaining accuracy.
**Early Diagnosis (Timepoint = BL)**

* **Semantic Fluency Results**
* This test involves a patient naming as many unique words in a semantic category (animals,fruit,vegetables) during 3 60 second time periods with the total score being the total number of uniques words produced
**Early Diagnosis (Timepoint = BL)**

* **Symbol Digits Modality Test**
**Early Diagnosis (Timepoint = BL)**

* **PIGD**
**Early Diagnosis (Timepoint = BL)**

* **Initial symptoms at diagnosis**
* **Primary Diagnosis**
* One of 25 diagnosis availiable

* **DaTSCAN Section**

## Volume Results
https://hackmd.io/jrmR9BnbTyu246Ph63Umvg

## Project 171 Results
https://hackmd.io/_j--ESF6T8-NXMq4JNB8vg

## DTI - Mean Diffusivity Results
https://hackmd.io/bObjycVJTT-Bx6MIrmJcDQ

## DTI - Fractional Anisotropy
https://hackmd.io/JLi361teTX-ZoJwehlC-nA

## REM Sleep Data