Capstone Meeting Minutes 13/8/2019
===

###### tags: `Capstone` `Meeting`

## SMART BioSym

:::info

- **Location:** Unconfirmed
- **Date:** Nov 1, 2030 2:30 PM (CET)
- **Agenda**
1. Self Intro
2. Project Intro
3. Discussion
4. Going through of capstone requirements
- No service pillar, all pillars required
- show them how does a sample proposal look like.
- 6k payment
- **Participants:**
- Xiaomeng
- Wei Ying
- Marcus Koh
- Chi Seng
- Jing Yu
- Kerwin Kwek

:::

**Meeting Minutes:**

**Description of research**
- Blood diagnostic system
- Microchips to do diagnostics on. Allow nurses to have an easy way to get diagnostics with one touch
- Working with companies on systems to test cells
- Cell therapy (Stem), need to know the quality of cells and select the best of the sample for the patient. Need to understand the biology aspect of that. These technologies will help with stem cell research etc.
- More Bio heavy
- Microfluidics
- Think pregnancy kits. The channels are micro in size and the fluids run in the channels.
- How do we scale up the product.
- Cost. Not really scalable

**Project Outline**
- The challenge is connecting tubings to get the fluids to flow. This is done on a micro scale.
- Pressure system to drive the fluid, real pressurized system or syringe or absorption system. Something to detect what is in the fluid.
- Imaging software
- Software, how to analyse and make sense of the patients data. Needs to control all the elements, when to start/stop analysing cells, when to capture images etc.
- User interface for the users to interact with the machine.
- PoC now is based on the pressure and image system.

**Project Outcome**
- The product must be able to interface with 5 different chips (Chip agnostic).
- Eventual product will involve real time evaluation of the statistics. This component will contribute to the data visualisation aspect
- We will be doing the imaging, pressure system and software. The end product will be scalable, can be deployed for many use cases.

## Skills breakdown
Need EPD students to draft out circuit on breadboard and eventually prototype it on a PCB.
Hardware to interface RPi and arduinos.

**Mech Design**
- How to drive motors for pressure, optimize the design part for the interfacing to connect to tubes etc. Vibrations - anti vibration dampening
- Optics to find out where light is coming from.

**Software**
- CV to detect the position of the chip and move the machine to where it is.
- Counting cells automatically, and with the correlation, we can map it to a knowledge base of known diseases.
- Computer Vision to help develop the data bank.

**User Interface**
- LCD touch screen for users to interact with. Encasement, 3D printing.

*Outcome*
We will be doing the imaging, pressure system and software. The end product will be scalable, can be deployed for many use cases.

Short term goal: mobilised in a real world facility.

## Internal Discussion
### ST Eng Cyber Sec
- C2C
- Allow operators to monitor and manage the living lab
- Deploy detection and mitigation
- Dashboards and webapp.
- IoT Sensor Network
- City wide IoT network including weather monitoring
- Enterprise IT Network
- simulation. Just need to integrate to our system.
- Industrial Control Network (Get rid of it)
- water test bed.

#### Tasks
- [ ] 1 ISTD who can webapp and 1 ESD/ASD.
- [ ] Scale down further by getting rid of ICN
- [ ]

## Notes 18/9/2019
### TODO (put x in bracket if done)
- [x] Forward confirmation from Kerwin bout attendance (Jy: forwarded to capstone email)
- [x] At least a ppt for the capstone scoping.
- Background of what we aim to achieve
- Scoping
- Deliverables etc
- [x] Send Kerwin slides and email kerwin to ask to meet.

## Slides review

These are my comments:

1) For "What is sepsis", I would remove most of the words and put point form. and one slide is sufficient.
2) I have attached some slides on background of the project which you might wanna use IF it is helpful for the presentation.
3) It is not "Camp's research. Rather, "current research"
- The microfluidic technology has been developed and clinical trials in NUH-ED are on-going
- A preliminary prototype has been developed comprise of a based pressure chamber, pressure controller, custom compact microscope, imaging system with laptop controlled python software to record videos.

4) Should have a slide stating the problems with it. Namely,

- Still requires a trained user to handle the system, thus
- not easily deployed in field.
- prone to user error for chip handling
- increase safety risk in sample loading process
- Manual/batch data analysis of raw video exported from system. (no real-time results)
- More data on performance of diagnostic chip is required. (i.e. deploying system in ED will enable more recruitment of patient and faster testing turnaround time)

5) For EACH person, i would assign an over arching goal. For example,
>Jing Yu: Electrical system intergation.
>Wei Ying: Microfluidic Integration.
>Yi Leng: System Design..

This will make it clearer on which part each person will do. I can help with this if needed.

6) Keep in mind that 15min presentation time... So stay concise in slides that needs to be concise. Focs on the important part of the presentation of what the presentation is for...If I did not interpret wrongly,
- it is to ensure that the scope is sufficient for FYP
- can be achieved during the timeframe and funding
- It will excite everyone!

Also something minor:

Message kerwin regarding the current goals, if it differs from what is already out there and are there already clinical trials ongoing for the device.

Contact Mentor(s): Prof, Jongyoon Han (SMART-MIT), Dr Kerwin Kwek (SMART)
SUTD Faculty Advisor: Assoc Prof Ye Ai. He just got promoted =)!