---
# System prepended metadata

title: COG-UK data flows

---

COG-UK data flows 
===

```mermaid
graph LR
    
    COG_climbs[COG sequence] --> COG_PHEs[COG<br>sequence]
    
    COG_climbv[COG variant] --> COG_PHEv[COG variant]
    subgraph CLIMB
    COG_climbs
    COG_climbv
    end

     subgraph PHE
    COG_PHEv
    COG_PHEs
    end
    
    
    
   COG_PHEs -.-> COG_Is[COG sequence API]
    subgraph ISARIC4C analysis platform
    ISARIC4C
    COG_Is
    PHOSP
    GenOMICC
    end
    
    COG_climbv --> COG_otherv[COG variant]
    subgraph Other PHAs
    COG_otherv
    end
    
    COG_otherv[COG variant]--> COG_othertre[COG variant]
    subgraph Other National TREs
    COG_othertre
    end
    
    
    COG_PHEv --> COG_ONSv[COG variant]
    subgraph ONS SRS
    COG_ONSv
    end
    
    COG_Is -.-> COG_OPEN[COG mutations of interest - via API]
    COG_Is -.-> COG_vd
    COG_Is -.-> COG_othertre
    subgraph OpenSafely
    COG_OPEN
    COG_vd[COG variant determination - via API]
    end
    
COG_PHEs -.-> COG_GELs[COG sequence for GenOMICC patients and 100,000 genomes]
subgraph Genomics England
COG_GELs
end


    
    

    
classDef default fill:#bec3e8,stroke:#333,stroke-width:1px,text-align:center;
    classDef datasource fill:#ffc6c6,stroke:#333,stroke-width:0px,font-weight:bold,text-align:center;
    classDef clinical fill:#67b599,stroke:#333,stroke-width:0px,font-weight:bold,text-align:center;
    class ICNARC,cv,cs datasource
    class lcd_ONS,lcd_NHSD,lcd_GEL,lcd_SAIL,lcd_IMP clinical

```