# NIPBL

- 1st session:
- With 25 new articles on the rare growth disorder, it shows that research on the disease continues to make sense. (Oder so ähnlich)
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| Gene name | Alternative Gene name| Protein name | Alternative Protein names | | | | |
| -------- | -------- | -------- | --- | --- | --- | --- | --- |
| NIPL | SCC2, IDN3 | Nipped-B-like protein | Delangin, SCC2 homolog | | | | |

The Nipped-B-like gene, alternatively called SCC2 or IDN3, is located on chromosome 5 band p13.1 in humans. [40] The gene encodes the Nipped-B-like protein, also known as delanginin, which plays an important role during the cell cycle. [41,43]
> [40] Krantz, I. D., McCallum, J., DeScipio, C., Kaur, M., Gillis, L. A., Yaeger, D., Jukofsky, L., Wasserman, N., Bottani, A., Morris, C. A., Nowaczyk, M. J. M., Toriello, H., Bamshad, M. J., Carey, J. C., Rappaport, E., Kawauchi, S., Lander, A. D., Calof, A. L., Li, H.-H., Devoto, M., Jackson, L. G. (2004). Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B. Nature genetics 36/6, 631–635.
> [41] Tonkin, E. T., Wang, T.-J., Lisgo, S., Bamshad, M. J., Strachan, T. (2004). NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome. Nature genetics 36/6, 636–641.
> [43] Nasmyth, K. (2011). Cohesin: a catenase with separate entry and exit gates? Nature cell biology 13/10, 1170–1177.