--- title: Endfeet disqus: hackmd --- Endfeet === :::success > Documentation [name=MrDr.Staffan] ###### tags: `page`, `endfeet` ::: :::info ### Table of Contents [TOC] ::: [Top](#Table-of-Contents) **Why this page?** Endfeet --- See Restraction by laser ablation. (or FRAPing?) https://www.nature.com/articles/s41598-018-37419-4 # Endfeet Simon 2018 [2018 J Neurosci Res. A transcriptome-based assessment of the astrocytic dystrophin associated complex in the developing human brain](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995340/) dystrophin associated complex (DAC) is what is being looked at. " human transcriptome data from male and female subjects across several developmental stages and brain regions to characterize the gene expression profile of the dystrophin associated complex (DAC), a known structural component of the astrocytic endfoot that supports perivascular localization of the astroglial water channel aquaporin-4 (AQP4)" Includes Slc9a3r1 ## Dtna [![](https://i.imgur.com/ZV7pIPR.jpg "DTNA" =200x)](https://www.proteinatlas.org/ENSG00000134769-DTNA/tissue/basal+ganglia#img) # Boulay AC 2019 [See Data RNAseq_Mm_AstrocyteEndFeet](https://docs.google.com/spreadsheets/d/1UK5-CQIvNXKXGvyeegkGSg0yy_qjVSQT9agwiE52myY/edit#gid=1918952779) Astrocyte endfeet perivascular membranes remain attached to mechanically isolated brain vessels. Mild BL enzymatic digestion might detach them and possibly deplete brain vessels of astrocyte perivascular mRNAs => [Many of these are Ependymal markers]