---
title: Axon guidance
disqus: hackmd
---
:::success
> Documentation [name=MrDr.Staffan]
###### tags: `axon_guidance`

### Table of Contents
[TOC]
:::
[Top](#Table-of-Contents)

# PDFs

[Axon guidance I](https://drive.google.com/file/d/13iTpxtk0VRgbqIokOAFEtnhZ5VeY9k0g/view?usp=sharing)
[Axon guidance II](https://drive.google.com/file/d/13f9M6U95Guu7-3FpmGkZCiFTsjJ3QLtl/view?usp=sharing)

https://www.frontiersin.org/articles/10.3389/fnins.2021.678454/full

# Semaphorins

[Sharma2](https://docs.google.com/spreadsheets/d/1ExKN0yQ0-Cv7HjRLVrnQza-T9s0_j9_Pf92G7IDfzx8/edit#gid=1431753340&range=A46)

Semaphorins are usually cues to deflect axons from inappropriate regions, especially important in the neural system development. The major class of proteins that act as their receptors are called plexins, with neuropilins as their co-receptors in many cases

https://drive.google.com/file/d/13iTpxtk0VRgbqIokOAFEtnhZ5VeY9k0g/view?usp=sharing

Sema3a is influenced by cGMP.
Dendrites rich in cGMP are attraceted to Sema3a
Axons lacking cGMP are repelled by Sema3a

Coreceptor. Plexin activation promotes Ras/RapGAP activity intrinsic to the plexin cytoplasmic domain and regulates downstream molecules,
including GEFs (LARG, RhoGEF, and FARP) (Pasterkamp, 2012).

# Plexins
# Slit:s
# Draxin

# RGM
RGMA
Repulsive Guidance Molecule BMP Co-Receptor A

# Ephrin
Repels the migrating axon away from the site of Eph/ephrin activation

Promote angiogenesis

EPHRINA
ligand EPHA

EPHRINB
ligand EPHB

ephrin-As and ephrin-Bs have been shown to mediate cellular responses that are distinct from those associated with activation of their corresponding receptors. Specifically, ephrin-A5 was shown to stimulate growth cone spreading in spinal motor neurons[12] and ephrin-B1 was shown to promote dendritic spine maturati

# Wnt
[See Epigenetics](https://hackmd.io/@sholmqvist/BJpKurTBB/%2FFTG3zDLIRjOQtrWE2DD6gg#Epigenetic-regulation-of-astro--neuro-genesis)

[](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201129/#:~:text=Astrocytic%20domains%20have%20been%20proposed,to%20be%20determined%20(21).)

# SFRP
Secreted Frizzled Related Protein 1

# SHH
# Netrin
NTN1
NTN2
NTN3

NTNG1 Netrin-G1
NTNG2 Netrin-G2
LRRC4 Netrin-G Ligand 2
LRRC4B Netrin-G Ligand 3 // Lrig4
LRRC4C Netrin-G Ligand 1
# BMP
Bone morphogenic protein **is NOT**
[See Bis(monoacylglycero)phosphate (BMP)](https://hackmd.io/wHYAtIKfSXesgS1hQW2iWg#endosomal-amp-lysosomal-membranes)

# FGF