Plasmid DNA Manufacturing Market Size, Comprehensive Research Study, Demand, Growth and Forecast to 2024-2035

Plasmid DNA serves as a vector for gene delivery in gene therapy, offering a transformative approach for the treatment of rare, inherited and acquired diseases as well as those previously deemed incurable.

The global plasmid DNA manufacturing market size is estimated to grow from USD 102 million in 2023 to USD 539 million by 2035, representing a CAGR of 14.85% during the forecast period 2023-2035.

The production of antigens for vaccines, facilitated by plasmid DNA, has revolutionized disease prevention strategies, specifically during the COVID-19 pandemic. Moreover, plasmid DNA has inherent flexibility and reproducibility, which has led to its adaptability in the production of personalized medicine and precision therapies, resulting to a paradigm shift in patient-centric healthcare. Enhanced techniques for gene editing and targeted gene therapy may arise, driven by plasmid-based platforms.

With advancements in synthetic biology, plasmid DNA has the potential to enable the construction of intricate genetic circuits, further fueling the development of novel therapeutics. Driven by the growing technological innovation and rising demand for cell and gene therapy products, DNA / RNA vaccines, the plasmid DNA manufacturing market is anticipated to witness a healthy growth in the foreseen future.

In recent years, plasmid DNA service providers are focused on widening their capabilities to offer multiple grades of plasmid DNA in order to meet the growing demand across various pharmaceutical applications, including basic research, drug discovery studies, as well as clinical and commercial applications.

Plasmid DNA Manufacturing Market Segmentation

Plasmid DNA Manufacturing Market segments include Distribution by Scale of Operation (Commercial, Clinical and Preclinical), Application Area (Cell Therapy Manufacturing, Gene Therapy Manufacturing, DNA / RNA Vaccine Development, Viral Vector Manufacturing, and Other Application Areas), Therapeutic Area (Metabolic Disorders, Neurological Disorders, Oncological Disorders, Rare Disorders, and Other Disorders), and Geography (North America, Europe, Asia, Latin America, Middle East and North Africa, and Rest of the World).

In fact 45% of the players offer both GMP plasmid manufacturing as well as research grade plasmid manufacturing services. 40% of the companies engaged in this domain have the capabilities to operate at all three scale of operation.

Leading Key Players in the Plasmid DNA Manufacturing Market

Key players in Plasmid DNA Manufacturing Market are AGC Biologics, Aldevron, Biomay, Catalent Pharma Solutions, Charles River, Cytovance Biologics, Forge Biologics, GenScript ProBio, Thermo Fisher Scientific, and VGXI. Examples of such firms include (in alphabetical order, large and very large firms based in US) AGC Biologics, Ajinomoto Bio-Pharma Services, Aldevron (acquired by Danaher), Catalent Pharma Solutions, Charles River and GenScript ProBio (a Subsidiary of GenScript). This is followed by those capable of operating at preclinical scale which are about 30%.

It is worth highlighting that 50% of the acquisition deals in Plasmid DNA Manufacturing Market are inked with the purpose of geographical expansion. Further, portfolio addition as well as expansion were identified as other key drivers. Examples of entire company acquisitions for both geographical consolidation and portfolio expansion, include (in reverse chronological order) the acquisition of e-Zyvec by PolyPlus (February 2022), Nature Technology by Aldevron (January 2022) and Vigene Biosciences by Charles River (May 2021).In order to build a sustainable competitive edge in the market, companies are actively focusing on offering end-to-end plasmid DNA services, from plasmid construction, plasmid design, plasmid engineering to manufacturing process development and optimization services.

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