# Patho Micro Block II ## Immunological disorder ### Vol 13 * 一. PA0030 (25)Amyloidoma, lung, 54F(P.3) * amorphous, hyaline, extracellular deposits * 裂縫 * histiocyte & multinucleate giant cells * 二. PA0061 (43)Acute cellular rejection, liver, 49F (P.26) * mixed portal inflammatory infiltrate * bile duct injury (上皮受傷): 發炎細胞浸潤 & 上皮受損 (質紅有小泡和排列不規則) * endotheliitis (小血管受傷): 發炎細胞 & 內皮受損 (lifted from basement membrane) * 三. PA0086 (69) Chronic rejection, kidney, 57F(P.43) * T-cell mediated * tubulointerstitial pattern: tubilitis (mononuclear cells) & interstitial inflammation (lymphocytes) * vascular pattern: endotheliitis (lymphocytes) * Antibody mediated * glomerulitis (mononuclear cells) & peritubular capillaritis (neutrophil or mononuclear cells) * Chronic * intimal thicken with inflammatory infiltration * glomerulopathy * interstitial fibrosis * 四. PA0261(191) Pneumocystis jiroveci pneumonia (P.75) * intra-alveolar eosinophilic foamy proteinaceous material with pneumocystis jiroveci trophic form * type II pneumocyte hyperplasia & chronic interstitial septum fibrosis * 五. PA0264 (193)Allergic rhinitis (P.105) * basement membrane thickening * 發炎浸潤: lymphocyte, plasma cell, eosinophilic (allergic) * squamous metaplasia ## Childhood disease ### Vol 14 * 一. PA0085 (68) Nephroblastoma (Wilms’ tumor), soft tissue(kidney) * triphasic: blastemal, stromal, epithelial * blastemal: 小藍圓 * stromal: spindle * epithelial: 像壞掉的 tubules 或 glomeruli structure,圍成 lumen * 二. PA0131 (107) Neuroblastoma, adrenal gland * 小藍圓 (-blastoma) * neuronal differentiation: * neuroblast: neuropil 背景, Homer-Wright pseudorosettes * ganglion cells: 核偏心 ### Vol 15 * ~~PA0247~~ PA0167, PA0168, PA0196 (142) Retinoblastoma, eye * 小藍圓 * Flexner-Wintersteiner rosette * Fleurette * PA0200 (146) Hyaline membrane disease, lung * eosinophilic hyaline membrane: fibrin + cell debris * collapsed alveoli * Teratoma * 呼吸上皮、角質化鱗狀上皮、皮脂腺、毛囊 ## Epithelial tumor ### Vol 16 * 一. PA0046 (31) Pleomorphic adenoma (mixed tumor), parotid gland * epithelial + mesenchyme element * Epithelial * duct: ductal cell + myoepithelium (核偏心像 plasma cell, cytoplasm 空亮 clear, spindled or epithelioid [cuboid]) * Mesenchymal * modified myoepithelium * myxod * 二. PA0047 (32) Squamous cell carcinoma, esophagus * invasive * squamous eddy, keratinization, intercellular bridge * LOSS of nuclear orientation and maturation * 三. PA0249 (38) Adenocarcinoma, colon * glandular differentiation ### Vol 17 * 一. PA0101 (82) High-grade squamous intraepithelial lesion, cervix, 43F * 沒有侵犯: 侷限在基底膜以上 * 二. PA0102 (83) Squamous cell carcinoma, uterine cervix, 61F ### Vol 18 * 一. PA0142 (118) Basal cell carcinoma, lip, 83M * 二. PA0207 (151) Familial adenomatous polyposis, large intestine, 20F ## Mesenchymal tumor ### Vol 19 * 一. PA0100 (81) Malignant melanoma, vulva, 55F * 二. PA0104 (85) Leiomyoma, uterus, 43F * 三. PA0154(130) Desmoid-type fibromatosis (Desmoid tumor), soft tissue (abdominal wall), 35F ### Vol 20 * 一. PA0257 (131)Myxoid liposarcoma, thigh, soft tissue (p.3) * chicken-wired capillaries * lipoblast * 二. PA0156 (132)Lymphangioma, soft tissue (leg) (p.22) * 三. PA0195 (134)Neurofibroma, plexiform and diffuse, cheek (p.36) ### Vol 21 * 一. PA0158 (135) Schwannoma, soft tissue, near T-level vertebra(P.3) * Antoni A, B * 二. PA0226 (167) Embryonal rhabdomyosarcoma, soft tissue(P.33) * primitive round and spindled cell * 三. PA0107 (88) Mature cystic teratoma, ovary(P.49) ## Cardiovascular system ### Vol 22 * 一. PA0170 (2)Atherosclerosis, 68M (P.3) * 二. DEMO:PA0169 Atherosclerosis, 57M, heart, coronary artery(P.23) * 三. PA0171 (3)Amyloidosis, myocardium (P.26) ### Vol 23 * 一. PA0001 (4) Infective endocarditis, mitral valve, 60M (P.3) * 二. PA0004 (6) Myocardial infarction, heart, 54M(P.13) * 三. PA0002 (5) Cardiac myxoma, heart, left atrium, 68F (P.34) * 四. PA0197 (143)Acute rheumatic pancarditis(P.49) * 五. PA0266 Cavernous hemangioma(embryonal rhabdomyosarcoma; soft tissue) (老師投影片誤植成 PA0226) (P.73) ## Respiratory system ### Vol 24 * 一. PA0174(19)Adenocarcinoma, lung, 58M(P.4) * 二. PA0018(20)Small cell carcinoma, soft tissue(lung), 82M(P.19) * 三. PA0021 (22) Squamous cell carcinoma, lung, 60M (p.25) * 四. PA0023 (23) Invasive mucinous adenocarcinoma, lung, 78F(p.49) ### Vol 25 * 一. PA0024(24)Bronchopneumonia, lung, 72F(P.3) (& Diffuse alveolar damage) * 二. PA0040(26)Diffuse alveolar damage, lung, 52M(P.27) * 三. PA0041(27)Mesothelioma, pleura, 56M(P.41) * 四. PA0263(192)Pneumoconiosis (P.58) ## Summary ### 器官 * kidney: nephroblastoma (Wilm's tumor), chronic rejection * lung: amyloidoma, hyaline membrane disease, diffuse alveolar damage, bronchopneumonia, small cell carcinoma, squamous cell carcinoma, adenocarcinoma, invasive mucinous adenocarcinoma * PCP vs. hyaline membrane disease