Collection of Medical Articles/Trusted Sources on COVID-19

# Collection of Medical Articles/Trusted Sources on COVID-19 ## Millenials (using ages 20-44) @ Risk? YES!! Today at the White House they said that the Italian data shows that Millenials are at risk. See e.g. [here](https://www.statnews.com/2020/03/18/u-s-official-says-data-show-severe-coronavirus-infections-among-millennials-not-just-older-americans/). But the data on [wiki](https://en.wikipedia.org/wiki/2020_coronavirus_pandemic_in_Italy#Statistics) or in the JAMA [article](https://jamanetwork.com/journals/jama/fullarticle/2763401) only show that a significant percentage of millenials are contracting the disease. But the US data now does show that severity is significant among this group. Look up this CDC [report](https://www.cdc.gov/mmwr/volumes/69/wr/mm6912e2.htm?s_cid=mm6912e2_w) which indicates that while the death rates are low among millenials, severity of the symptoms is significant. In fact, of the COVID-19 cases, 29% are millenials, and they account for 20% of the hospitalized and 12% of the ICU admits. And the millenials form a [third](https://www.populationpyramid.net/united-states-of-america/2019/) of the US population. ## Simulation from Washington Post [Interesting Simulations:](https://www.washingtonpost.com/graphics/2020/world/corona-simulator/) For those among us who are quantitatively oriented. ## Scientific American [Placeholder for all COVID-19 Articles:](https://www.scientificamerican.com/report/the-new-coronavirus-outbreak-what-we-know-so-far/) Here you will find all the articles from Scientific American on the Corona virus. And below, I highlight a few of them. 1. [On a Likely Source of the Virus and the Possibility of Future Pandemics:](https://www.scientificamerican.com/article/how-chinas-bat-woman-hunted-down-viruses-from-sars-to-the-new-coronavirus1/) *Wuhan-based virologist Shi Zhengli has identified dozens of deadly SARS-like viruses in bat caves, and she warns there are more out there.* 2. [On the Downfall of COVID-19 With Rise in Tempertaure:](https://www.scientificamerican.com/article/what-could-warming-mean-for-pathogens-like-coronavirus/) Some of the folks back home have mentioned that as Chennai hits 42c, COVID-19 will dissipate. This article says, *Even if it does turn out to have some seasonal components in the future, that effect will likely be small this year, experts say. Since it's a new disease with very little immunity built up in the human population, it will likely continue to spread quickly.* ## The Often Quoted Imperial College Report #### The report which is guiding the UK and US response [Washington Post Summary of it:](https://www.washingtonpost.com/world/europe/a-chilling-scientific-paper-helped-upend-us-and-uk-coronavirus-strategies/2020/03/17/aaa84116-6851-11ea-b199-3a9799c54512_story.html?utm_campaign=wp_to_your_health&utm_medium=email&utm_source=newsletter&wpisrc=nl_tyh&wpmk=1) [NYTimes - Behind the Virus Report That Jarred the U.S. and the U.K. to Action:](https://www.nytimes.com/2020/03/17/world/europe/coronavirus-imperial-college-johnson.html) [The Report Landing Page:](https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/) *..We show that in the UK and US context, suppression will minimally require a combination of social distancing of the entire population, home isolation of cases and household quarantine of their family members. This may need to be supplemented by school and university closures, though it should be recognized that such closures may have negative impacts on health systems due to increased absenteeism. The major challenge of suppression is that this type of intensive intervention package – or something equivalently effective at reducing transmission – will need to be maintained until a vaccine becomes available (potentially 18 months or more) – given that we predict that transmission will quickly rebound if interventions are relaxed. We show that intermittent social distancing – triggered by trends in disease surveillance – may allow interventions to be relaxed temporarily in relative short time windows, but measures will need to be reintroduced if or when case numbers rebound. Last, while experience in China and now South Korea show that suppression is possible in the short term, it remains to be seen whether it is possible long-term, and whether the social and economic costs of the interventions adopted thus far can be reduced.* On this page you will find at the bottom a [link](https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/covid-19-information/) to multiple sources for guidance on COVID-19. ## Lancet - A British Medical Journal [Placeholder for COVID-19 Articles:](https://www.thelancet.com/coronavirus) *To assist health workers and researchers working under challenging conditions to bring this outbreak to a close, The Lancet has created a Coronavirus Resource Centre. This resource brings together new 2019 novel coronavirus disease (COVID-19) content from across The Lancet journals as it is published. All of our COVID-19 content is free to access.* They say that the articles are available to the public. Let me know if you cannot access any of interest to you. [Clinical course and mortality risk of severe COVID-19:](http://homepage.divms.uiowa.edu/~nshyamal/public/covid19/MortalityRisk.pdf) This comment was published March 17th; has some useful nuggets of quantitative info. For example, drawing from a JAMA article from the Chinese center for disease control, it says that *current best estimate is that about 81% of people with COVID-19 have mild disease*. Also, it gives data on viral shedding by affected survivors (a range of 8-37 days from the onset of symptoms), and on comorbidity rate of patients hospitalized and the high death rates among them. [Prevention in those with decompensated cirrhosis:](http://homepage.divms.uiowa.edu/~nshyamal/public/covid19/Cirrhosis.pdf) We have a family member with this condition, so I thought I should highlight this. Also it has a rather nice panel on "Preventive messages and measures for patients with decompensated cirrhosis in our study" which has some useful tips for others as well. ## JAMA - Journal of the American Medical Association [Landing Page:](https://jamanetwork.com/journals/jama/pages/coronavirus-alert) They have a trove of useful information. [Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China](https://jamanetwork.com/journals/jama/fullarticle/2762130) This is the most comprehensive report, but given how rapidly things are developing it is a bit dated (2/24). ## On the Stability of the Corona Virus [Summary of a New England Journal of Medicine article:](https://www.nih.gov/news-events/news-releases/new-coronavirus-stable-*hours-surfaces) While SARS-CoV-2, the virus causing COVID-19, can be stable for hours or days depending on the surface, ... read the summary linked above. [The Underlying NEJM article:](https://www.nejm.org/doi/full/10.1056/NEJMc2004973?query=featured_home) *The longest viability of both viruses was on stainless steel and plastic;* and copper seems the best. ## New England Journal of Medicine [Landing Page](https://www.nejm.org/) 1. [Informative Audio Interview on the Search for Effective Therapeutics](https://www.nejm.org/doi/full/10.1056/NEJMe2005759?query=featured_home) 2. [First Randomized Trial:](https://www.nejm.org/doi/full/10.1056/NEJMoa2001282?query=featured_home) I am impressed with the sophistication of the Chinese medical system that I am coming to know through these readings. Here is a first randomized control trial done remarkably early. Unfortunately, the results are not promising. ## Mortality by Age - Chinese CDC Report [Article from CCDC:](http://weekly.chinacdc.cn/en/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51) See Table 1 for mortality rates by age. I recently heard that the Italian experience is different. I will try to get a source behind this statement from the The White House. ## From 1mg.com - India's Largest Healthcare Platform [Pretty Good E-book:](https://www.1mg.com/coronavirus-covid19) This was pointed to me by Bamini, and is a pretty good summary. Since the science is evolving rapidly, it is not completely accurate. For example, what it says on the stability of the virus contradicts the recent NEJM article above. ## Worldometers.info - Interesting website with much of the above data [Landing Page for Coronavirus](https://www.worldometers.info/coronavirus/):