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Intrahost variation in MPXV

The following image summarizes SNPs (no indels) found in four samples from BioProject PRJNA845087.

The image is interactive. Clicking on bars of the histogram of change counts (yellow bars) will restrict the image to that subset of changes.

The image has the following panels:

Top panel

Distribution of detected changes across MPXV genomes (accession MP903343). The Y axis is the alternative allele frequence. Each change is depicted using two marks:

  • circle = corresponds to median AF across samples. Size of circle corresponds to the number of samples conatining this change
  • vertical rule = vertical rule shows the spread of AFs of inidividual samples (from min to max)

Lower panel left

Histogram of substitution types. Clicking on any bar will restrict the entire graph to these changes.

Lower panel middle

Histogram of 5'-context

Lower panel right

Histogram of 3'-context


010,00020,00030,00040,00050,00060,00070,00080,00090,000100,000110,000120,000130,000140,000150,000160,000170,000180,000190,000200,000Genome position0.00.20.40.60.81.0AF010203040CountA>CA>GA>TC>AC>TG>AG>CG>TT>AT>CT>GChange (REF->ALT)05101520CountTGGGCGTCATAGCATAACGTCCTTAAGAGCCTPrefix010203040CountGACACGGCTAACAACTGTATTTCCTCAGTGGGSuffix.MISSENSENONSENSESILENTEffect1234Numberof samples