---
# System prepended metadata

title: Single-Unit Stability Using Chronically Implanted Multielectrode Arrays
tags: [論文摘要, 穩定性]

---

# Single-Unit Stability Using Chronically Implanted Multielectrode Arrays

###### tags: `論文摘要` `穩定性`

- Link: https://doi.org/10.1152/jn.90920.2008
- MLA: Dickey, Adam S., et al. "Single-unit stability using chronically implanted multielectrode arrays." Journal of neurophysiology 102.2 (2009): 1331-1339.
- 年分: 2009
- 期刊: Journal of neurophysiology


### 目的

判斷channel的穩定與否

### 啟發

> [Chen, Daofen, and Eberhard E. Fetz. "Characteristic membrane potential trajectories in primate sensorimotor cortex neurons recorded in vivo." Journal of Neurophysiology 94.4 (2005): 2713-2725.](https://doi.org/10.1152/jn.00024.2005)

不同神經會有不同的ISIH圖形

![https://journals.physiology.org/cms/10.1152/jn.00024.2005/asset/images/medium/z9k0100549840002.jpeg](https://journals.physiology.org/cms/10.1152/jn.00024.2005/asset/images/medium/z9k0100549840002.jpeg)

![https://journals.physiology.org/cms/10.1152/jn.00024.2005/asset/images/medium/z9k0100549840004.jpeg](https://journals.physiology.org/cms/10.1152/jn.00024.2005/asset/images/medium/z9k0100549840004.jpeg)

### 方法簡述

使用sorted unit的waveform和interspike interval histogram (ISIH)作為判斷穩定的依據

- waveform
    - 神經放電所造成的電壓圖案
    - The waveform similarity score (W) was defined as the Pearson's correlation coefficient computed between the two averages of the sorted waveforms
- inter-spike interval(ISI)
    - 將同一個片段的spike訊號之間的間隔依序計算出來即為ISI
    - The ISIH score (I) comparing the similarity between two sets of ISIH parameters, A and B, is defined as

        $I(A,B)=\sqrt{ \sum_{i=1}^8 \frac{(A_i-B_i)^2}{\sigma_i^2} }$

所計算出來的穩定度與時間關係如圖

![https://journals.physiology.org/cms/10.1152/jn.90920.2008/asset/images/medium/z9k0080996310009.jpeg](https://journals.physiology.org/cms/10.1152/jn.90920.2008/asset/images/medium/z9k0080996310009.jpeg)

範例

- waveform穩定, ISIH 穩定

![https://journals.physiology.org/cms/10.1152/jn.90920.2008/asset/images/medium/z9k0080996310006.jpeg](https://journals.physiology.org/cms/10.1152/jn.90920.2008/asset/images/medium/z9k0080996310006.jpeg)

- waveform穩定, ISIH 不穩定

![https://journals.physiology.org/cms/10.1152/jn.90920.2008/asset/images/medium/z9k0080996310007.jpeg](https://journals.physiology.org/cms/10.1152/jn.90920.2008/asset/images/medium/z9k0080996310007.jpeg)