---
# System prepended metadata

title: Intra-day signal instabilities affect decoding performance in an intracortical neural interface system
tags: [論文摘要, 穩定性]

---

# Intra-day signal instabilities affect decoding performance in an intracortical neural interface system

###### tags: `論文摘要` `穩定性`

- Link: https://doi.org/10.1088/1741-2560/10/3/036004
- MLA: Perge, János A., et al. "Intra-day signal instabilities affect decoding performance in an intracortical neural interface system." Journal of neural engineering 10.3 (2013): 036004.
- 年分: 2013
- 期刊: Journal of neural engineering


透過分析當天(within-day)以下變量判斷穩定性

- spike rates
- spike amplitudes
- 解碼性能影響

發現

- 系統性的spike rate變化很常見
    - 會導致解碼器的輸出發生方位的偏差
    - 變化來自紀錄的震幅、雜訊、以及生理的變化
- 大部分變化發生在局部區域，而非整體

說明

- 因為紀錄的時間非常短暫，所以血管搏動和腦內壓力變化不太可能造成紀錄變化
- spike記錄的不穩定可能成因
    - 電極與紀錄神經元之間小於50µm的相對運動
    - 劇烈運動導致紀錄神經元的改變(shifting population of neurons)
- spike震幅改變可能成因
    - 細胞內鈉離子通道活性(不過這個的影響時間只有約20秒)
    - 生理狀態(ex: sleep/wake cycles)
    - 習慣動作(activity dependent attenuations driven by experience)也會造成震幅下降

        > [Quirk, Michael C., Kenneth I. Blum, and Matthew A. Wilson. "Experience-dependent changes in extracellular spike amplitude may reflect regulation of dendritic action potential back-propagation in rat hippocampal pyramidal cells." Journal of Neuroscience 21.1 (2001): 240-248.](https://www.jneurosci.org/content/21/1/240.full)

結果

- 安裝電極2個月firing rate與firing amplitude的變化

    ![](https://i.imgur.com/V41sJw0.png)
    ![](https://i.imgur.com/9kfwnll.png)
