Predicting protein/nucleic acid complexes with RoseTTAFoldNA

# Predicting protein/nucleic acid complexes with RoseTTAFoldNA Dear RNA enthusiasts! Next week join us our second RNA CASP SIG meeting with a presentation from, Dr. Frank DiMaio: *Predicting protein/nucleic acid complexes with RoseTTAFoldNA* Zoom link Tuesday June 6 Pacific Time 8am / Eastern Time 11am / Central European Time: 5pm / China Standard Time: 11pm If you have recommendations on topics of discussion or speakers, please feel free to email us as well. We aim to meet virtually monthly to discuss the state of and new developments in our community. https://groups.google.com/g/casp-rna-sig and click "Ask to join group" See you! Rachael Kretsch (Rhiju Das and Wah Chiu labs @Stanford) Marcin Magnus (Elena Rivas lab @Harvard) # BIO Dr. Frank Dimaio is an Associate Professor at the Institute for Protein Design. His research is focused on protein structure determination from sparse and noisy experimental data. By combining ideas from protein structure prediction with data-guided conformational sampling, we may uniquely determine a protein’s structure to atomic accuracy in cases where neither data nor prediction alone is sufficient. The methods Frank has developed include tools for solving difficult molecular replacement problems, elucidating more than a dozen structures previously unsolved in the laboratories of expert crystallographers. He has also developed a new approach for low-resolution crystal refinement; this method outperforms state-of-the-art refinement packages, making it possible to infer detailed atomic interactions from low-resolution crystal data]. Frank is further interested in developing tools for de novo structure determination from low-resolution data, as well as extending these approaches to other sources of data. Additionally, he is more generally interested in structure prediction, developing methods for improving conformational sampling, protein forcefield development, and modeling (and design) of symmetric protein assemblies. Improvements to structure prediction – both sampling methods and forcefields – are critical to designing proteins with novel function. # YOUTUBE PLAYLIST For recording see [playlist here](https://www.youtube.com/playlist?list=PLRX3RsMqVcfr0xKSJIepkXSRLufAGU7sC), expect a few day delay after each zoom, we will specify if seminars will not be recorded. We wanted to highlight talks from the CASP conference including the top 4 groups and assessment teams. These are excellent places to learn about the state of the art methods as well as overview of the prediction quality from assessors: Aichemy_RNA2 - Peng Xiong Chen group - Shi Jie Chen RNApolis - Marta Szachniuk GeneSilico - Janusz M. Bujnicki RNA assessment - Eric Westhof RNA assessment - Rhiju Das RNP assessment (9:27 onwards) - Tom Mulvaney Zoom link: https://stanford.zoom.us/j/93445935624?pwd=K0VUWk0zaVNMZlU1U0xUMS8vSWUwZz09