# Abstract The joint Python Accelerators project gathers developers of Transonic, Cython, Pythran, Numba and scikit-image. The goal of our collaboration is to improve the state of Python acceleration so that clean and modern Python code can easily be accelerated to reach high performance. We propose to improve interoperability and compatibility between existing accelerators. We will first improve the integration and feature coverage of the Pythran support in Cython, which will have a strong impact on many Cython codes already written. Moreover, we will base our work on a new package called Transonic, which can accelerate one code with different accelerators, with just-in-time and ahead-of-time compilations. We propose to work on the usage of Transonic in scikit-image, which is a good example of a widely used library that relies a lot on Cython while its developers would love to be able to write cleaner and simpler Python and to also use Numba and Pythran as accelerators. While working on scikit-image code, we will improve its maintainability and its performance. We will also improve the accelerators by fixing bugs, implementing missing features and increasing performance. This will have a direct impact on life sciences through the improvement of many Python packages. More generally, this one-year project will greatly improve the state of the scientific Python ecosystem. There will be one tool adapted for both developers of fundamental libraries (like scikit-image) and simple users (like scientists and students), with a clean API and good documentation. Moreover, this short-term project will launch a long-term dynamics on performance for scientific Python, based on compatibility, interoperability and gentle competition between the accelerators. The Joint Python accelerators project will for example be aware of the new and promising projects HPy and EPython, which would allow scientific codes to be executed efficiently with PyPy.