Conferences inherently create environments that facilitate the spread of infectious diseases, by bringing people together from various parts of the world — many of whom will have been in recent close proximity to large numbers of people due to air travel. Given the infectivity and immune-evasion capabilities of newer COVID-19 variants, it is almost a statistical certainty that there will be COVID-positive attendees at any typical conference.
Two-way masking with FFP2/N95 or better masks, that is, masking by all participants and not just by those who know they are at greater risk, is the most effective means of preventing COVID transmission and consequent risks to health.
Recent variants are significantly more transmissible and able to evade immune protection from current vaccines
Enhanced transmissibility, infectivity, and immune resistance of the SARS-CoV-2 omicron XBB.1.5 variant
In late 2022, the SARS-CoV-2 omicron BQ.1 and XBB lineages, characterised by amino acid substitutions in the spike protein that increase viral fitness, had become predominant in the western (BQ.1) and eastern (XBB) hemispheres. The BQ.1 lineages are descendants of BA.5, whereas the XBB lineage is the recombinant of two highly diversified BA.2 lineages.
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Experiments using lentivirus-based pseudoviruses also showed approximately 3-fold increased infectivity of XBB.1.5 compared with XBB.1. These results suggest that XBB.1.5 exhibits a remarkably strong affinity to the human ACE2 receptor, which is attributed to the S486P substitution. Moreover, neutralisation assay revealed that XBB.1.5 was robustly resistant to BA.2 breakthrough infection sera (41-fold versus B.1.1, 20-fold versus BA.2) and BA.5 breakthrough infection sera (32-fold versus B.1.1, 9.5-fold versus BA.5).