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# System prepended metadata

title: Blood Components & Safety

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# Blood Components & Safety

## Blood Screening

**Blood donations are screened for 5 Pathogens + 1 new:** 

| Pathogen | NAT (pathogen nucleic acids) | Serology (IgG) |
| -------- | ---------------------------- | -------------- |
| HIV      | V                            | V              |
| HCV      | V                            | V              |
| HBV      | V                            | V              |
| HTLV     | X                            | V              |
| Syphylis | X                            | V              |
| WNV      | V (June-Oct)                 | X               |


**Emerging Non-Tested Pathogens**
CMV, Chagas, Malaria

## Blood Components

### Preserving Blood Donations

#### 1. Anticoagulation

**Main anticoagulant used**
Citrate

**Main advantage**
Short T1/2 -> doesn't impact recipients coagulation

**MOA**
Ca2+ chelator

**Side Effects**
Hypocalcemia (mostly in children)

#### 2. Nutrients for ATP synthesis
Phosphate, Dextrose, Adenine


**Comparing Preservation Solutions**

|                              | CPDA | ADSOL / SAG-M  |
| ---------------------------- | ---- | -------------- |
| Citrate                      | V    | V              |
| Phosphate, Dextrose, Adenine | V    | V (++ Adenine) |
| Mannitol                     | X    | V              |
| Duration preserved?          | 35d  | 42d            |

