# IWBDA2020 Lab Automation 1.2: 🍒 CERISE 🍒 ## **C**herrypick-**E**fficient **R**educed **I**nstruction **S**et **E**ngine <p style="font-size: 0.9rem;font-style: italic;"><img style="display: block;" src="https://upload.wikimedia.org/wikipedia/commons/3/3a/Cherry02.svg" alt="File:Cherry02.svg" width=200><a href="https://commons.wikimedia.org/w/index.php?curid=35231380">"File:Cherry02.svg"</a><span> by <a href="https://commons.wikimedia.org/wiki/User:JohannPoufPouf">JohannPoufPouf</a></span> is licensed under <a href="http://creativecommons.org/publicdomain/zero/1.0/deed.en?ref=ccsearch&atype=html" style="margin-right: 5px;">CC0 1.0</a><a href="http://creativecommons.org/publicdomain/zero/1.0/deed.en?ref=ccsearch&atype=html" target="_blank" rel="noopener noreferrer" style="display: inline-block;white-space: none;margin-top: 2px;margin-left: 3px;height: 22px !important;"><img style="height: inherit;margin-right: 3px;display: inline-block;" src="https://search.creativecommons.org/static/img/cc_icon.svg" /><img style="height: inherit;margin-right: 3px;display: inline-block;" src="https://search.creativecommons.org/static/img/cc-cc0_icon.svg" /></a></p> **Alexis Casas and Jeremy Cahill** ## Introducing 🍒CERISE - 🍒**CERISE** is a project to optimize biolab robot instruction sets. - Given a cherry-pick list, we will output a reduced instruction set executable by a robot. - Cherry-picking lists are "universal" and can be interpreted by most platforms. - They can be generated both manually and algorithmically. ## Scope - Today, researchers write most cherry-picking lists by hand in spreadsheet software. - Actions in a protocol are usually grouped and executed sequentially. - ex. distribute the water and the master mix before the DNA. - We want to optimize these essential protocol steps in a reduced instruction set. - The engine will group these actions as instructions, optimizing along objective functions. - ex: distribute the same reagent in one go, save time, save tips. ## Proof of Concept - For our proof of concept, we will target the Opentrons OT-2 platform. - We have selected this platform because it is affordable, open-source, and widely-adopted. - Therefore it is accessible to the greatest number of labs possible. ## Deliverables - Reduced instruction set - See: Linked proposal for 'Testify' system - Definition of the cherry-picking list schema - Software to transform the cherry-picking list into instructions - Instruction set implemented on one open platform: the Opentrons OT-2 ## Links - [IWBDA2020 Lab Automation Pitch Notes](https://hackmd.io/43yXR751QCylQfsZ6Kk7lw) - [Autoprotocol](https://autoprotocol.org) - [Opentrons](https://opentrons.com)