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Nitrate and nitrite modulate mitochondrial respiration through NO synthesis. Two recent studies by the same research group showed that plasma NO metabolites like nitrate and nitrite increased significantly after nitrate treatment. The efficiency of human mitochondria, assessed in vitro by oxygen consumption per molecule of ATP produced (phosphate/oxygen ratio), was significantly enhanced with respect to a placebo group after intake of 0.1 mmol/kg sodium nitrate for 3 days. Interestingly, studies involving beetroot juice have also reported a significant increase in plasma nitrite levels (regarded as markers of NO) after intake of beetroot juice. 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Nitric oxide supplementation improves cardiac health, enhances performance during exercise, improves healing, reduces erectile dysfunction, reduces high blood pressure during pregnancy and improves respiratory response. <h2 style="text-align: center;"><a href="https://www.glitco.com/get-Animale-Nitric-Oxide-US">(ACT NOW & SAVE) Click Here to GET Animale Nitric Oxide Booster From The Official Website</a></h2> The benefits associated with NO have mostly been obtained in moderately trained individuals. Two prevalent NO supplements are L-arginine and L-citrulline. L-arginine is involved in NO synthesis. L-arginine supplements increase respiratory response and enhance performance during exercise. L-citrulline is a L-arginine precursor that is converted into NO by a reaction catalyzed by NOS. L-citrulline combined with malate and other molecules increase working capacity. Many studies on beetroot juice report a significant increase in plasma nitrite levels, a NO marker, after intake of beetroot juice. Similarly, glycine propionyl-L-carnitine and 2-(nitroxy) ethyl 2-amino-3-methylbutanoate are dietary supplements that act as nitric oxide donors, enhance nitric oxide synthesis and may also stimulate NO synthesis through expression of the eNOS gene.