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# System prepended metadata

title: Notebook Giuliano Ballacchino

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# Notebook Giuliano Ballacchino

## **1 Grundidee:** Aufklärungsarbeit innerhalb verschiedener Gesellschaftsgruppen 

### Schwerpunkt Schule:

### Schwerpunkt Politik:

### Schwerpunkt Wirtschaft:

### Schwerpunkt Wissenschaft:






* Erstellung von Einzelpostern
* Zusammenfürung zu einem Gesamtwerk?
* Werbevideo?



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## 2. Grundidee: Globaler Mutationsverlauf des SARS-CoV-2


=> **Poster**
 
 * **Varianten des SARS-CoV-2**

 1.) COVID-19 and mutations a threat level assessment
 https://pubmed.ncbi.nlm.nih.gov/33868743/
 
 2.) Higher infectivity of the SARS-CoV-2 new variants is associated with            K417N/T, E484K, and N501Y mutants: An insight from structural data
 https://pubmed.ncbi.nlm.nih.gov/33755190/
 
 3.) Mutations in SARS-CoV-2 SRA Data
 https://www.ncbi.nlm.nih.gov/labs/virus/vssi/#/scov2_snp
 

* **FASTA/BLAST/uniprot Vergleiche der Mutationen**

1.) Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome
https://www.ncbi.nlm.nih.gov/nuccore/1798174254

https://www.ncbi.nlm.nih.gov/protein/?term=Covid+19+mutation

2.) Expression vector SARSCoV2SD614G, complete sequence
https://www.ncbi.nlm.nih.gov/nuccore/MW560960.1

3.) Severe acute respiratory syndrome coronavirus 2 data hub
https://www.ncbi.nlm.nih.gov/labs/virus/vssi/#/virus?SeqType_s=Nucleotide&VirusLineage_ss=Wuhan%20seafood%20market%20pneumonia%20virus,%20taxid:2697049&utm_source=gquery&utm_medium=referral&utm_campaign=COVID-19

4.) Mutations in SARS-CoV-2 SRA Data
https://www.ncbi.nlm.nih.gov/labs/virus/vssi/#/scov2_snp

* **Ursprung der Mutationen**
* **Globale Verteilung der Mutationen**

1.) https://covariants.org/variants/S.N501

https://phylodynamics.pandemicprepardness.org/SARS-CoV-2/Germany?dmax=2020-04-14&dmin=2020-03-08&l=radial


* **Detektion von Mutationen**

 1.) Rapid screening for SARS-CoV-2 variants of concern in clinical and environmental samples using nested RT-PCR assays targeting key mutations of the spike protein
https://pubmed.ncbi.nlm.nih.gov/33857895/

 2.) PCR assay to enhance global surveillance for SARS-CoV-2 variants of concern
 https://pubmed.ncbi.nlm.nih.gov/33758901/

* **Detektierte Mutationen in Deutschland**

1.) https://docs.google.com/spreadsheets/d/1G-2TAslg1KOOlHayxVd8WMEia2wln02j_OerBHZjpnA/edit#gid=0

* **Unterschiede in Bezug auf die Sequenzen der verschiedenen Varianten** 
* **Mutationen vs. Impfstoff**

 1.) The British variant of the new coronavirus-19 (Sars-Cov-2) should not create a vaccine problem
https://pubmed.ncbi.nlm.nih.gov/33377359/



* **Zukunftsaussichten (positive/ negative Mutationen)**








https://clades.nextstrain.org/tree


![](https://i.imgur.com/crR0uF9.png)

https://www.ncbi.nlm.nih.gov/labs/virus/vssi/#/tree?job_id=JSID_01_321002_130.14.18.128_9000__flu_blast

https://www.ncbi.nlm.nih.gov/labs/virus/vssi/#/align?job_id=JSID_01_320998_130.14.18.128_9000__flu_blast


**Webseiten zur Visualisierung**

https://datavizcatalogue.com
https://www.r-graph-gallery.com

https://biorender.com
fontawesome
bioicons

![](https://i.imgur.com/9rUJBai.jpg)
