# Alicia Oberländer

## Erste Ideen:

_Infektion_
- Infektion von SARS-CoV-2 -> Was passiert im Körper bei einer Infektion?
- Warum paar Menschen sehr schwere Verläufe? Was passiert in der Lunge? Warum/Wann Beatmung nötig?
- Verlauf von schweren Fällen -> ARDS
- Aufklärung von Long-COVID

_Mutationen_

- Was sind Mutationen? Welche Mutationen gibt es bei SARS-CoV-2 -> Was für Unterschiede machen die Mutationen aus?

_Impfstoff_

- Einfacher Vergleich der Impfstoffe und dessen Wirkungsweise

-> Aufklärung von "Nicht-Wissenschaftlern" in Form von Postern oder Video, einfache Gestaltung

Infographic über ARDS oder Corona allgemein?
Arbeitsblatt für Schüler im Abi (Bio-Leistungskurs)?
Infoblatt ARDS für Arztpraxis/Lungenarzt im Warteraum?

**Hauptidee: Flyer/Poster über Aufklärung der Infektion mit Corona und Auswirkungen**

## Paper: Long-COVID

**Pubmed**

Autonomic dysfunction in ‘long COVID’: rationale, physiology and management strategies
https://www.rcpjournals.org/content/clinmedicine/21/1/e63

Pathogenesis of COVID-19-induced ARDS: implications for an ageing population
https://reader.elsevier.com/reader/sd/pii/S0277953620306456?token=6C6A8B0FFADCFB01BAD454A7320E354B50E497E4DDF1787B1576A7E7D7171E8D496CAB4C1C54C21BF749DA7B9051CB2B&originRegion=eu-west-1&originCreation=20210420112936

## Paper: ARDS

**Google** **Suche**

**Pathogenesis of COVID-19-induced ARDS:
implications for an ageing population**
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397945/pdf/ERJ-02049-2020.pdf
- Vergleich der Pathogenese von Infuenza ARDS und COIVD-ARDS
- Infuenza-ARDS:
- überwiegend Frauen betroffen
- geringer Gehalt an IFN-gamma -> Schützender Effekt (Immunregulation)
-
- COVID-ARDS:
- überwiegend Männer betroffen
- starke IFN-gamma Immun Antwort
- Risikofaktor: Alter (Hallmarks of aging)


**Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians**
https://www.resmedjournal.com/action/showPdf?pii=S0954-6111%2820%2930379-6

**A Testimony of the Surgent SARS-CoV-2 in the Immunological Panorama of the Human Host**
https://www.frontiersin.org/articles/10.3389/fcimb.2020.575404/full


**Compartmental immunophenotyping in COVID-19 ARDS: A case series** (2021 Jan)
https://pubmed.ncbi.nlm.nih.gov/32979342/
- We consecutively included patients less than 72 hours after intubation following informed consent from their next of kin. Bronchoalveolar lavage fluid was evaluated by microscopy; bronchoalveolar lavage fluid and blood were assessed by 10-color flow cytometry and a multiplex cytokine panel.
- **COVID-19 ARDS exhibits a distinct immunologic profile in the lungs, with a depleted and exhausted CD4 and CD8 T-cell population that resides within a heavily hyperinflammatory milieu.**

**ECMO Paper**
Extracorporeal Membrane Oxygenation (ECMO) in Critically Ill Patients with Coronavirus Disease 2019 (COVID-19) Pneumonia and Acute Respiratory Distress Syndrome (ARDS)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430351/

**Acute respiratory distress syndrome (ARDS) caused by the novel coronavirus disease (COVID-19): a practical comprehensive literature review**
- ARDS: Diagnose, Behandlung, Phänotyoen etc.
https://www.tandfonline.com/doi/pdf/10.1080/17476348.2020.1820329?needAccess=true

**Virology, transmission, and pathogenesis of SARS-CoV-2**
https://www.bmj.com/content/371/bmj.m3862
In severe disease, excessive immune response leads to organ damage, intensive care admission, or death. The viral load peaks in the first week of infection, declines thereafter gradually, while the antibody response gradually increases and is often detectable by day 14

**Video: SARS CoV2 immunology**
https://www.youtube.com/watch?v=YIvtrh6Z3OQ

- Robuste Interferon Immunantwort (Milde/moderate Fälle)
- schwere Fälle: hohe Anzahl an Monozyten
- Immunzellen werden aus dem Blut zu den Lungen rekrutiert -> wenig Immunzellen (Neutophiles, Monozyten)im Blut
- Balance zwischen anti- und pro-inflammatorische Cytokine
- langsame Interfreron Antwort -> schwere Fälle -> Cytokin Storm
- Hyperinflammation

https://www.youtube.com/watch?v=rpmUG6pb0zs&t=335s

# Tools

Piktogramme
https://biorender.com/features/