# Bupropion **Student**: Ema Sedlić *Biotechnology and Drug Research* **Class:** Informatics **Rijeka 2024.** --- ## What is bupropion? <span style="font-size: 35px;"> <div style="display: flex; justify-content: space-between;"> <div style="width: 100%;"> <p> Bupropion is an antidepressant medication used to treat depression and seasonal affective disorder, it also supports smoking cessation and weight management. It is the active ingredient in Wellbutrin and Zyban, Auvelity contains bupropion and dextromethorphan, and Contrave contains bupropion and naltrexone. </p> </div> </span> <img src="http://hackmd.io/_uploads/HJT2VTGwA.jpg" title="Wellbutrin pakiranje" width=380 height=400 align="center" style="margin: 20px;"> --- ## chemical formula $$C_{13}H_{18}ClNO$$ ## synthesis 1-(3-chlorophenyl)-2-propanone + 2-chloroethanol $$C_{10}H_{10} + ClCH_{2}CH_{2}OH \to C_{13}H_{18}ClNO$$ --- ```mermaid= %%{init: {"themeVariables": { "pie1": "#ff9999", "pie2": "#66b3ff", "pie3": "#99ff99", "pie4": "#ffcc99"}}}%% pie title Applications of Bupropion "Antidepressant" : 60 "Smoking Cessation" : 30 "ADHD" : 5 "Weight Loss" : 5 --- ```mermaid graph LR; A[Prons and Cons of Bupropion] A --> B[Prons] A --> C[Cons] B --> D[Increased energy] B --> E[Less impact on sexual function] B --> F[Less risk of manic episodes] C --> G[Increased anxiety] C --> H[Seizure risk when combined with alcohol] C --> I[Headaches] --- ### RDKit structure: | Bupropion structure | Dopamine structure | | --------------- | -------------------- | |  |  | --- ### Avogadro: -bupropion <img src="https://hackmd.io/_uploads/BJsN2zEv0.jpg" width= 550 height=400 align="center"> --- ### Pymol: -DAT protein (4XP4 structure) <img src= "https://hackmd.io/_uploads/BJlL2f4vR.jpg" width=550 height=400 align="center"> --- ## Side Effects of Bupropion <div style="font-size: 25px; line-height: 1.5;"> 1. **Dry Mouth**: Often reported by users; staying hydrated can help manage this. 2. **Insomnia**: Difficulty sleeping, typically alleviated by taking the medication earlier in the day. 3. **Headache**: Can be managed with over-the-counter pain relievers. 4. **Nausea**: Taking the medication with food may reduce this symptom. 5. **Sweating**: Increased perspiration, especially at night. 6. **Constipation**: Increased fiber intake and hydration can help alleviate this. </div> --- <div style="font-size: 30px; line height: 1.5;"> ## PubChem info | Parameter | Value | |------------------|----------------| | **Molecular Mass** | 239.7 g/mol | | **Melting Point** | 234-238 °C | | **Solubility in Water** | 25 mg/L | | **Bio Half-Life** | 21 hours | | **Main Use** | Antidepressant, smoking cessation, weight management | | **Side Effect Frequency** | 10-20% (dose dependent)|</div> --- ## Pharmacokinetics  --- ## Image sources: * Wellbutrin: [Medical uses-Wiki](https://en.wikipedia.org/wiki/Bupropion) * Pharmacokinetics: [Mechanism of action](https://psychscenehub.com/psychinsights/bupropion-mechanism-of-action-psychopharmacology-clinical-application/) > For more info just click [here](https://pubchem.ncbi.nlm.nih.gov/compound/Bupropion#section=IUPAC-Name)