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title: Podcast talking points and refs

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# Podcast talking points and refs

- Ageing biology
	- Fundamentals / theories of Ageing
		- ...
		- Antifragility of populations through evolution - mere robustness of the individual
		- (https://www.goodreads.com/book/show/13530973-antifragile)
		- Selection shadow - Selection pressure is reduced with age after sexual maturity (Haldane and Medawar)
		- Antagonistic Pleitropy - genes have multiple functions, thus there are trade offs when they are selected (George Williams)
		- Ageing as an Information Transmission Problem
			- @jenkinsonPotentialEnergyLandscapes2017a (http://www.ncbi.nlm.nih.gov/pubmed/28346445)
			- non-equilibrium statistical mechanics 
				- life's ratchet by Peter Hoffman
					- https://www.goodreads.com/book/show/16691583-life-s-ratchet
				- Every life is on fire by Jeremy England 
					- https://www.goodreads.com/book/show/50358530-every-life-is-on-fire 
					- https://www.preposterousuniverse.com/podcast/2020/10/26/120-jeremy-england-on-biology-thermodynamics-and-the-bible/
					- https://www.youtube.com/watch?v=10cVVHKCRWw
				- Scale by Geoffrey West (Part 4.6 is most pertinent) https://www.goodreads.com/book/show/31670196-scale
				- Simulating biological systems with analog comuptation makes some of the problems more computatoinally tractable see: Sara Achour's work https://people.csail.mit.edu/sachour/
		- Use it or loose it ~ African Turquoise Killifish
	- Chalenges of intervention
		- pleiotropy (having multiple functions - thus unintended consquences)
		- The challenge of testing efficacy in humans
			- utility of Ageing clocks as a proxy
				- DNAm clocks (@horvathDNAMethylationAge2013) () 
				- rat/human clock
		- biology as a legacy code problem (XKCD DNA https://xkcd.com/1605/)
		- The epigenetic Landscape
			- getting 'up' is all well and good but can you get 'down' again with the desired function and without cancer?
		- Future of genetic interventions: Hacking Darwin by Jamie Metzl (https://www.goodreads.com/book/show/40597264-hacking-darwin)
	- Viable interventions now
		- Basically the standard lifestyle advice
		- Drugs/supplements (quite small effect sizes)
			- NAD+ (NMN,NR) (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842119/)
			- metformin (https://doi.org/10.1016/j.cmet.2020.04.001)
			- rapamycin (case for rapamycin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/)
		- Parabiosis - Transfusion of young blood/plasma (not very practical)
		- Senolytics - potentially promising new area
		- Accessible sources of news
			- Rhonda Patrick - www.foundmyfitness.com 
			- Peter Attia - https://peterattiamd.com/
		- Books (by ageing researhers)
			- Lifespan by David Sinclair https://www.goodreads.com/book/show/43723901-lifespan
			- Age Later by Nir Barzilai https://www.goodreads.com/book/show/51174975-age-later
			- The Ageless Generation by Alex Zhavoronkov https://www.goodreads.com/book/show/16059458-the-ageless-generation
			- The Mystery of Human Ageing by Bjoern Schumacher https://www.goodreads.com/book/show/34956972-the-mystery-of-human-aging
- Cryonics
	- Rabit liver?
	- subcellular activity maybe important in neurons - not convinced a network map is enough
	- vitrification process still not perfected so still getting some ice crystals and therfore cell damage
	- DNR issues
- prortein structure AI stuff?


