# Podcast talking points and refs - Ageing biology - Fundamentals / theories of Ageing - ... - Antifragility of populations through evolution - mere robustness of the individual - (https://www.goodreads.com/book/show/13530973-antifragile) - Selection shadow - Selection pressure is reduced with age after sexual maturity (Haldane and Medawar) - Antagonistic Pleitropy - genes have multiple functions, thus there are trade offs when they are selected (George Williams) - Ageing as an Information Transmission Problem - @jenkinsonPotentialEnergyLandscapes2017a (http://www.ncbi.nlm.nih.gov/pubmed/28346445) - non-equilibrium statistical mechanics - life's ratchet by Peter Hoffman - https://www.goodreads.com/book/show/16691583-life-s-ratchet - Every life is on fire by Jeremy England - https://www.goodreads.com/book/show/50358530-every-life-is-on-fire - https://www.preposterousuniverse.com/podcast/2020/10/26/120-jeremy-england-on-biology-thermodynamics-and-the-bible/ - https://www.youtube.com/watch?v=10cVVHKCRWw - Scale by Geoffrey West (Part 4.6 is most pertinent) https://www.goodreads.com/book/show/31670196-scale - Simulating biological systems with analog comuptation makes some of the problems more computatoinally tractable see: Sara Achour's work https://people.csail.mit.edu/sachour/ - Use it or loose it ~ African Turquoise Killifish - Chalenges of intervention - pleiotropy (having multiple functions - thus unintended consquences) - The challenge of testing efficacy in humans - utility of Ageing clocks as a proxy - DNAm clocks (@horvathDNAMethylationAge2013) () - rat/human clock - biology as a legacy code problem (XKCD DNA https://xkcd.com/1605/) - The epigenetic Landscape - getting 'up' is all well and good but can you get 'down' again with the desired function and without cancer? - Future of genetic interventions: Hacking Darwin by Jamie Metzl (https://www.goodreads.com/book/show/40597264-hacking-darwin) - Viable interventions now - Basically the standard lifestyle advice - Drugs/supplements (quite small effect sizes) - NAD+ (NMN,NR) (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842119/) - metformin (https://doi.org/10.1016/j.cmet.2020.04.001) - rapamycin (case for rapamycin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/) - Parabiosis - Transfusion of young blood/plasma (not very practical) - Senolytics - potentially promising new area - Accessible sources of news - Rhonda Patrick - www.foundmyfitness.com - Peter Attia - https://peterattiamd.com/ - Books (by ageing researhers) - Lifespan by David Sinclair https://www.goodreads.com/book/show/43723901-lifespan - Age Later by Nir Barzilai https://www.goodreads.com/book/show/51174975-age-later - The Ageless Generation by Alex Zhavoronkov https://www.goodreads.com/book/show/16059458-the-ageless-generation - The Mystery of Human Ageing by Bjoern Schumacher https://www.goodreads.com/book/show/34956972-the-mystery-of-human-aging - Cryonics - Rabit liver? - subcellular activity maybe important in neurons - not convinced a network map is enough - vitrification process still not perfected so still getting some ice crystals and therfore cell damage - DNR issues - prortein structure AI stuff?