To customize the homepage in the Twenty Twenty-Two WordPress theme to create a 2-column layout, you can follow these steps:

* Login to your WordPress admin dashboard.
* Go to `Appearance` and click `Customize`.
* In the Customizer, look for the `Utilities` or `Layouts` section, which may vary depending on the specific version of the theme.
* Click on the `Widgets` or `Layout` section to expand it.
* Look for the `Home Page` or `FrontPage` option. This option allows you to customize the layout of the homepage.
* Choose the `2-column` or similar layout option that suits your needs.
* Save changes and exit Customizer.

You can also create a custom homepage template using the page builder. To do this, you can follow the steps in this follow the steps outlined in this WPXPO blog post:

* Customize the `homepage` template from the `editor` settings. Click the plus icon and select the query loop block.
* Automatically add your site's posts to the page you're editing.
* Create a `new column block` and drag it to the right side of the page.
* Add the content you want to display in the right column.
* Save the changes and exit the editor.

By following these steps, you will be able to customize the Twenty-Two WordPress theme homepage layout to have a 2-column layout.

Note that the specific options and steps may vary slightly depending on the theme version you are using.