Lab1 - HackMD

Lab1 === 1. Find answers to the following questions about the human Angiotensin-converting enzyme 2 (ACE2) * What chromosome is ACE2 on? On Chromosome X - NC_000023.11.(“ACE2 Angiotensin Converting Enzyme 2 [Homo Sapiens (Human)] - Gene - NCBI”) * How many exons does this gene have? There are 22 Exons. (“ACE2 Angiotensin Converting Enzyme 2 [Homo Sapiens (Human)] - Gene - NCBI”)Another competing number is 18, from sciencedirect.com. (“Angiotensin-Converting Enzyme 2 - an Overview | ScienceDirect Topics”) * Briefly describe how the gene works. The protein translated from this gene catalyzes the reaction that cut angiotensin I into angiotensin 1-9 and the reaction that cut angiotensin II into the vasodilator angiotensin 1-7. The protein expressed by this protein may be important in regulating the cardiovascular and renal function, even fertility.(“ACE2 Angiotensin Converting Enzyme 2 [Homo Sapiens (Human)] - Gene - NCBI”) * What diseases are caused by mutations in the gene? Human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2. (“ACE2 Angiotensin Converting Enzyme 2 [Homo Sapiens (Human)] - Gene - NCBI”) * Where did you find this information? On the official website of ncbi. (“ACE2 Angiotensin Converting Enzyme 2 [Homo Sapiens (Human)] - Gene - NCBI”) * Find a paper that describes an aspect of ACE2's function Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. (RICE et al.) * What do you hope to learn in BIT150? I want to learn what are some tools for bioinformatics, what are exactlly bioinformatics, and what are works related to bioinformatics like. Works Cited * “ACE2 Angiotensin Converting Enzyme 2 [Homo Sapiens (Human)] - Gene - NCBI.” Www.ncbi.nlm.nih.gov, www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=59272. * Accessed 22 Sept. 2022.“Angiotensin-Converting Enzyme 2 - an Overview | ScienceDirect Topics.” Www.sciencedirect.com, www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/angiotensin-converting-enzyme-2. * RICE, Gillian I., et al. “Evaluation of Angiotensin-Converting Enzyme (ACE), Its Homologue ACE2 and Neprilysin in Angiotensin Peptide Metabolism.” Biochemical Journal, vol. 383, no. 1, 24 Sept. 2004, pp. 45–51, 10.1042/bj20040634. Accessed 2 Sept. 2020.